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故事发生在1865年的法国南部，流浪汉狄默提（纳威尔·佩雷兹·毕斯卡亚特 Nahuel Pérez Biscayart 饰）来到了这里，为了避人耳目，他假装自己是聋哑人，在这里的一座小村庄中住了下来。在村子里，狄默提邂逅了名为约瑟芬（伊希尔·勒·贝斯柯 Isild Le Besco 饰）的女子，美丽善良的约瑟芬一下子就吸引了狄默提的注意。 约瑟芬的父亲休斯（让-克劳德·古卢姆伯格 Jean-Claude Bolle-Reddat 饰）是一个热情好客的男人，他慷慨的邀请狄默提来家里做客，可休斯的善意却并没有得到狄默提的回报。狄默提用一种古老而又邪恶的方法催眠的约瑟芬，将她带进深山老林之中肆意凌辱。
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麦可(狄恩肯恩饰)在路上搭载了年轻性感的正妹(克莉丝汀波森饰)，麦可原先认为漫漫公路有正妹相伴艳福不浅，自以为遇上了豔遇的他，却不知道自己即将陷入一连串的阴谋及杀机，一趟没有终点的旅程即将展开… 故事描述一个男人在路途中载了一位年轻的女人，原来只是好心借人搭便车，结果男主人公却发现自己陷入了一场可怕的午夜梦魇…… If she looks too good to be true, then she absolutely is. Just ask Michael Anderson (Dean Cain), a gullible film editor who picks up a sexy young hitchhiker (Christie Burson) in the Arizona desert. After the most thrilling one night stand of his life, Michael becomes embroiled in a twisted love con involving a sadistic crime boss (Michael Madsen), a lonely henchman, and a thieving bank manager. Trust isn't just a bitch, it's a dirty little trick! A crime bosss money is missing and he wants it back by any ay means. The beautiful hitchhiker has it and wants to make the getaway. Alexander "Sasha" Shulgin is the scientist behind more than 200 psychedelic compounds - including MDMA, more commonly known as Ecstasy. Considered to be one of the greatest chemists of the 20th century, Sasha's vast array of discoveries have had a profound impact in the field of psychedelic research, making him a subject of fascination and controversy among fellow scientists and a folk hero to recreational users of psychedelics. Dirty Pictures uncovers the lifework of Dr. Shulgin and takes viewers inside his Northern California home where he lives with his wife of 40 years and continues to carry out experiments in a makeshift laboratory. Director étienne Sauret likewise delves into the broader world of psychedelic research - where the fields of chemistry, neuroscience and philosophy intersect - and investigates whether or not this particular field could aid in solving the deepest mysteries of the human mind.
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